Towards Solving the Blockchain Trilemma: An Exploration of Zero-Knowledge Proofs

Research on blockchain has found that the technology is no silver bullet compared to traditional data structures due to limitations regarding decentralization, security, and scalability. These limitations are summarized in the blockchain trilemma, which today represents the greatest barrier to blockchain adoption and applicability. To address these limitations, recent advancements by blockchain businesses have focused on a new cryptographic technique called Zero-knowledge proofs . While these primitives have been around for some time and despite their potential significance on blockchains, not much is known in information systems research about them and their potential effects. Therefore, we employ a multivocal literature review to explore this new tool and find that although it has the potential to resolve the trilemma, it currently only solves it in certain dimensions, which necessitates further attention and research

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′- dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescence of human cell cultures, and protects mice from prolonged myocardial ischaemia. Concomitantly, DMC induces autophagy, which is essential for its cytoprotective effects from yeast to mice. This pro-autophagic response induces a conserved systemic change in metabolism, operates independently of TORC1 signalling and depends on specific GATA transcription factors. Notably, we identify DMC in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine. In summary, we have identified and mechanistically characterised the conserved longevity-promoting effects of a natural anti-ageing drug